Multivariate analysis revealed that a high level of VEGF expression in tumor tissue (≥50% positive cells) was associated with reduced 5-year OS (54.3% vs. 82.6% in low-expression groups), and the VEGF expression and tumor T stage were independent prognostic factors for overall survival (HR = 2.573 and 4.953, respectively) [117]. The gene discussed is VEGFA; the disease is neoplasm.