In a landmark study, comprised of 65 HCC cases, 29 non-malignant neoplastic nodules (FNH, n = 10; large regenerative nodules, n = 6; low-grade dysplastic nodules, n = 3; HGDN, n = 7; and liver cell adenomas, n = 3) and 30 hepatolithiasis (as controls), HCCs exhibited diffuse CD34 positivity in >50% of sinusoidal cells (62/65 cases, 95.4%) alongside abnormal reticulin patterns characterized by thin, incomplete networks surrounding expanded trabeculae (>3 cell layers) [42]. The gene discussed is CD34; the disease is hepatocellular carcinoma.