PMS2 loss was significantly associated with female sex (18% vs. 8.4%, p = 0.015), right-sided tumor location (23.5% in right colon, 8.8% in left colon, and 7.2% in rectum; p = 0.003), and poor differentiation (24.8% in G3, 6.7% in G2, and 0% in G1; p < 0.001). Here, PMS2 is linked to neoplasm.