Pituitary neuroendocrine tumors (PitNETs), previously known as pituitary adenomas, are the most frequent benign tumors of the sellar region and are classified as microadenomas (micro-PitNETs) when the measure is less than 10 mm in diameter, or macroadenomas (macro-PitNETs), when the measure is greater than 10 mm in diameter [4]; of these, GH-secreting PitNETs account for approximately 20% and are benign neoplasms that lead to excess secretion of the hormone, manifesting as two clinical syndromes: acromegaly and gigantism [5]. The gene discussed is GH1; the disease is acromegaly.