Moreover, recent studies illustrate how diagnostic evaluation of GH-secreting PitNETs has progressed in highly specialized centers, where classification now includes not only clinical features and imaging characteristics, but also intraoperative tumor consistency (categorized as soft, intermediate, or fibrous), histological subtype, and the expression of pituitary transcription factors such as PIT1 and SF1 [117,118]. This evidence concerns the gene SF1 and neoplasm.