Furthermore, RNF213 protein, is implicated in carcinogenesis, as it has been reported in multiple studies associated with MM and other cancers [53], while, a member of the A-kinase anchor protein family, the AKAP13 gene, is expressed in a variety of cell types including bone marrow, and is associated with cellular proliferation and oncogenic transformation [54]. Here, AKAP13 is linked to Miyoshi myopathy.