Similarly, in patients with chronic obstructive pulmonary disease, Abd El-Kader et al. (2016) found that 12 weeks of aerobic exercise significantly decreased TNF-α, IL-2, IL-4, IL-6, and CRP levels, with reductions being significantly greater than those observed with resistance training (p < 0.05) [26]. The gene discussed is IL4; the disease is chronic obstructive pulmonary disease.