The primary aim was to undertake a structured narrative literature review reporting the mortality associations of non-steroidal anti-inflammatory drugs (NSAIDs), Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), exercise, arthroplasty, paracetamol, duloxetine (a SNRI (serotonin-norepinephrine reuptake inhibitor)), and opioids, each against a control population, for comparison in the context of osteoarthritis management. This evidence concerns the gene GCG and osteoarthritis.