Increased insulin levels associated with high BMI leads to a reduction in Insulin-Like Growth Factor Binding protein and increased the biological activity of IGF-1, which can increase angiogenesis needed for development of PCa via IGF-1 receptor as well as stimulate growth factors such as vascular endothelial growth factor (VEGF) [59,63]. The gene discussed is IGF1; the disease is posterior cortical atrophy.