This study identifies serum cystatin C as an independent predictor after full adjustment of stroke morbidity, all-cause and cardio-cerebrovascular mortality, with distinct nonlinear thresholds at 1.24 mg/L for stroke morbidity, all-cause mortality, and cardiovascular mortality, and at 1.81 mg/L for all-cause mortality in stroke patients. The gene discussed is CST3; the disease is stroke disorder.