IL6 and endometriosis: Furthermore, administration of omega-3 eicosapentaenoic acid (EPA), a precursor of E-series resolvins, in an endometriosis mouse model reduced the number of cystic lesions and expression of IL-6, and the 12/15-LOX pathway was key in the production of EPA metabolites for anti-inflammatory effects and suppression of endometriosis [75].