The role of ERK1/2 in inflammation has been demonstrated in bovine endometrial cells using different compounds, such as melatonin or progesterone, which inhibited LPS-induced ERK1/2 phosphorylation and inflammatory cytokines, and melatonin reduced endometrial fibrosis, a condition associated with bovine endometritis [65,66]. This evidence concerns the gene MAPK3 and endometritis.