CHGA and neuroendocrine carcinoma: Adenoma was excluded for the presence of metastases to the liver, spleen and pancreas; neuroendocrine carcinoma for the low mitotic activity and immunohistochemical characteristics (neuroendocrine carcinomas are identifiable immunohistochemically first for positivity to S100 as well as to chromogranin A and neuron-specific enolase).