Argininosuccinic acid (2545-fold) was cleaved by argininosuccinate lyase (ASL) into arginine and fumarate—the latter suppressing hypertension via KCNMB1 downregulation—while reducing glutathione (GSH) and elevating malondialdehyde (MDA) in brain tissues. Here, KCNMB1 is linked to Hypertension.