PTPN11 and acute myeloid leukemia: Germline mutations in PTPN11 were first observed in Noonan syndrome [110,111], while somatic mutations have been identified in myeloid malignancies such as juvenile myelomonocytic leukaemia (JMML), myelodysplastic syndromes (MDSs), and acute myeloid leukaemia (AML) [110,112,113].