Immunophenotypically, these cells express CD30 and CD15 but lack the CD45 and B-cell markers, such as CD20 [26]; (2) MCcHL that is the more prevalent in older adults and immunocompromised patients, especially those with HIV, this variant shows abundant classic HRS cells in a heterogeneous background of eosinophils, histiocytes, plasma cells, and neutrophils. This evidence concerns the gene PTPRC and Hodgkin's lymphoma, mixed cellularity.