The B-cell transcription factors OCT2 and BOB1 are particularly useful in challenging settings, as their expression is typically weak or absent in most cHL subtypes but is retained in LRcHL and strongly expressed in NLPHL, making these markers valuable in distinguishing these entities from other forms of cHL, which retain stronger B-cell phenotypes [7,53,60,61]. The gene discussed is POU2AF1; the disease is classic Hodgkin lymphoma.