The diagnostic features of NLPHL/NLPBCL are the following: (1) tumour cells (so-called “popcorn” or LP cells) exhibit strong expression of CD45 and B-cell markers (CD20, CD79a, BCL6, OCT2, BOB1 [34,35,36]; (2) unlike HRS cells of cHL, LP cells are typically negative for CD15 and CD30 [34,36]; (3) LP cells reside within nodules surrounded by a network of follicular dendritic cells and rosetting T-cells [37]; (4) EBV is almost never associated with NLPHL, unlike certain cHL subtypes (especially MCcHL and LDcHL) [37]. This evidence concerns the gene TNFRSF8 and Hodgkin's lymphoma, mixed cellularity.