In this regard, several studies have shown that SAHA treatment can increase the levels of acetylated histones such as Ac-H2A, Ac-H2B, Ac-H3, and Ac-H4, compared to the controls, which are known to contribute to the regulation of both the transcriptional and post-transcriptional mechanisms that can deactivate proliferation of cancer cells [10,11,12,13,14,18]. Here, H2BC21 is linked to cancer.