Other genes that are involved in PCNSL include CARD11, PRDM1, TBL1XR1, TNFAIP3, B2M, CDKN2A, KMT2D, TERT, KLHL14, ETV6, CD58, CIITA, etc. Somatic hypermutation (SHM) involved in PCNSL affects genes including IGHV4–34, BTG2, H1–4, KLHL14, MYC, PAX5, PIM1, RHOH, and SUSD2 [2,17,19,20,23]. This evidence concerns the gene KLHL14 and primary central nervous system lymphoma.