Other genes that are involved in PCNSL include CARD11, PRDM1, TBL1XR1, TNFAIP3, B2M, CDKN2A, KMT2D, TERT, KLHL14, ETV6, CD58, CIITA, etc. Somatic hypermutation (SHM) involved in PCNSL affects genes including IGHV4–34, BTG2, H1–4, KLHL14, MYC, PAX5, PIM1, RHOH, and SUSD2 [2,17,19,20,23]. Here, CARD11 is linked to primary central nervous system lymphoma.