In Kras^LSL G12D/+; p53^f/f mice engineered to express the ROR1 antigen, a relevant model for NSCLC and TNBC, CAR T-cells alone delivered after standard lymphodepletion (cyclophosphamide and fludarabine) showed poor tumor infiltration, rapid dysfunction, and only transient anti-tumor activity similar to what has been observed in clinical settings [174]. The gene discussed is ROR1; the disease is neoplasm.