EHE is a fusion-driven cancer, with more than 90% of patients positive for a t(1;3)(p36.3;q25) translocation that results in WW Domain-Containing Transcription Regulator Protein 1-Calmodulin-Binding Transcription Activator 1 (WWTR1-CAMTA1) gene fusion [4,5]. The gene discussed is WWTR1; the disease is cancer.