ROCK1 is an important effector molecule in the RET and Ezrin signalling pathways, as it promotes migration and chemotaxis of lung adenocarcinoma cells through interaction with Ezrin under the regulation of the RET signalling pathway [25,26], which involves cytoskeletal remodelling and enhancement of cell motility, thereby promoting tumour metastasis [27]. This evidence concerns the gene RET and lung adenocarcinoma.