Possible explanations for the limited effects of AA in Vero and RWPE1 cells may include the possession of robust enzymic and non-enzymic antioxidant defense mechanisms, such as higher levels of catalase and glutathione peroxidase, which efficiently neutralize H2O2 in these cells compared to cancer cells, thereby mitigating oxidative damage [49]; differential expression of AA transporters (sodium-dependent vitamin C transporters [SVCTs] and GLUTs) [50]; and enhanced DNA repair mechanisms in normal cells [27,51]. The gene discussed is CAT; the disease is cancer.