In similarity to studies focused on CRS, they showed that the serum Ang-2 concentration (p = 0.0003) and the Ang-2:Ang-1 ratio (p = 0.0014) were higher in patients with grade ≥ 4 neurotoxicity compared with those with grade ≤ 3 neurotoxicity. This evidence concerns the gene ANGPT2 and congenital rubella syndrome.