ANGPT2 and congenital rubella syndrome: Immune system activation is evident in CRS and ICANS, which leads to the release of several proinflammatory molecules from monocytes–macrophages, such as angiopoietin-2 (ANG-2), interleukins, and colony-stimulating factors (GM-CSFs), resulting in endothelial injury, platelet aggregation, increased vascular permeability, and disturbances in the blood–brain barrier (BBB) [10,17].