Serum markers indicative of endothelial dysfunction, including soluble vascular cell adhesion molecule 1 (sVCAM-1), soluble TNF receptor 1 (sTNFRI), thrombomodulin (TM), soluble C5b-9 (sC5b-9), VWF: Ag and angiopoietin-2 (α2-AP) were significantly higher in CAR-T cell patients at all the time points compared to healthy controls, while ADAMTS-13 activity (A13) was decreased in CAR-T recipients. The gene discussed is THBD; the disease is endothelial dysfunction.