Markers of endothelial damage, such as VCAM-1, ICAM-1, E-selectin, Ang-2, Ang-1, and Ang-2:Ang-1 ratio, have been found to be increased in patients with severe CRS and/or ICANS compared to those with mild or without toxicities, in several prospective studies [38,46,48,49,50,52]. Here, ANGPT2 is linked to congenital rubella syndrome.