Notably, increased serum VWF, as well as increased Ang-2:Ang-1 ratio, before both LD (p = 0.06, p = 0.05, respectively) and on day 1 after CAR-T infusion (p = 0.01, p-0.01, respectively), predicted severe CRS [49]. This evidence concerns the gene VWF and congenital rubella syndrome.