BRAF and neoplasm: For instance, a meta-analysis by Li C. et al., published in 2013, pooled 32 studies including 6372 patients with PTC, and found that BRAF-mutated PTC was significantly associated with larger tumor size, lymph node metastasis, extrathyroidal extension, advanced tumor stage, multifocality, tall cell variant histology of PTC, classic variant of PTC, and absence of a capsule [83].