Molecular studies have revealed the role of mortalin overexpression in promoting cancer cell proliferation, EMT, metastasis, stemness, and chemoresistance via multiple pathways, including Wnt/glycogen synthase kinase-3 beta/β-catenin, p53-p21WAF1, growth arrest and DNA-damage-inducible protein alpha, and mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) [12,13,14,28,29,30,31]. The gene discussed is HSPA9; the disease is cancer.