Mechanistically, the inhibition of mortalin led to the induction of p21WAF1 and E-cadherin, along with the downregulation of signal transducer and activator of transcription (STAT)-3 signaling and inhibition of matrix metalloproteinases (MMP)-2, MMP-9, Vimentin, Slug, Twist, Vascular endothelial growth factor (VEGF), β-catenin, c-Myc, and cyclin D1 expression in cancer cells in various studies [12,14,26,28,29,30,31,32,33]. This evidence concerns the gene HSPA9 and cancer.