TEK and colorectal carcinoma: Their presence correlated with tumor vascularity, growth, and metastasis in different human cancers, with up-to-date data obtained from studies on CRC xenograft mouse models providing strong evidence of similar effects in CRC patients supported by the positive correlation of TEM-related signaling molecules such as Tie2 and its downstream molecules, namely PI3K and AKT levels, and CRC disease stage, grade, MVD, and overall survival in human CRC patients.