Furthermore, TEMs are a crucial component of special tumor sites known as the tumor microenvironment of metastasis (TMEM), where Tie2 macrophages are in close direct contact with ECs, causing localized hyperpermeability that allows invasive, highly motile MENA+ (mammalian enabled protein) tumor cells to intravasate and metastasize [39]. The gene discussed is TEK; the disease is neoplasm.