ANG and neoplasm: In animal models, inhibition of Ang/Tie2 interaction in the COLO205 (human CRC cell line) xenograft mouse model using trebananib (AMG 386) caused inhibition of the proliferation of tumor-associated ECs [64], matching results of the inhibition of Ang2/Tie2 receptor interaction by a specific peptide known as CovX-Bodies in xenograft mice models injected subcutaneously also with the colon cancer cell line COLO205, which caused significantly reduced tumor vascular density and tumor growth, together with reduced frequency of tumor-infiltrating Tie2+ macrophages compared to controls [65].