Their presence correlated with tumor vascularity, growth, and metastasis in different human cancers, with up-to-date data obtained from studies on CRC xenograft mouse models providing strong evidence of similar effects in CRC patients supported by the positive correlation of TEM-related signaling molecules such as Tie2 and its downstream molecules, namely PI3K and AKT levels, and CRC disease stage, grade, MVD, and overall survival in human CRC patients. This evidence concerns the gene AKT1 and cancer.