Considering the undeniable importance of the Tie2 receptor in CRC, we carried out an extensive review of the literature and data from the Catalogue of Somatic Mutations in Cancer (COSMIC) to investigate the presence of any Tie2 mutations linked to CRC, and our search revealed no evidence of Tie2 receptor mutations associated with colorectal cancer CRC pathogenesis. The gene discussed is TEK; the disease is colorectal carcinoma.