In the field of hepatocellular carcinoma, several studies have suggested that integrins are closely related to TKI resistance; for example, ITGB8 mediates AKT stabilization through HSP90 and enhances the regulation of lenvatinib resistance through the AKT signaling pathway [14], and the overexpression of ITGA6 can increase the resistance of acute lymphoblastoid B cells to erlotinib [15]. Here, AKT1 is linked to hepatocellular carcinoma.