ICAM1 and neoplasm: Interestingly, bioinformatic analysis of the gene expression of genes involved in the immune and inflammatory response of cancer and normal tissue to IR revealed that among the 24 marker genes common to the response of normal and tumor tissue to IR, several are associated with endothelial activation, such as Vcam-1, Icam-1, E-selectin, as well as the NF-κβ protein family [44].