ADAM10 and neoplasm: Another study showed that IR of HUVECs with 2 or 4 Gy led to the elevated permeability of endothelial monolayers and transendothelial migration of tumor cells due to the degradation of Vascular Endothelial Cadherin (VE-Cad), as a consequence of up-regulation of ADAM Metallopeptidase Domain 10 (ADAM10) [24].