ESR1 and breast cancer: Of note is the systematic review and meta-analysis of prospective studies by Farvid et al. from 2021 [82], which found that total fruit and vegetable intake is associated with a lower risk of total breast cancer and postmenopausal breast cancer, as well as estrogen- and progesterone-receptor-positive (ER+/PR+) and negative (ER-/PR-) breast cancer.