TP53 and neoplasm: Increased expression or activity of oncogenes such as c-MYC [10], KRAS [11], BRAF [12], and HER2 [13] or inactivation of tumour suppressor genes such as P53 [14], BRCA1, and BRCA2 [15], can lead to uncontrolled cell division and the inhibition of cell death pathways [16,17].