These results are partially supported by studies that have demonstrated that radiation induces alterations in the tumor microenvironment; molecular pathways like mTOR and EGFR signaling; epigenetic modifications in recurring tumor cells; and several physical forces which lead to tumor regrowth with more resilience and aggressiveness, enhancing neurotoxicity and the loss of neuronal networks, leading to neurological disorders in GBM patients [17,24,34,40]. Here, EGFR is linked to nervous system disorder.