EGFR and cancer: In addition, HER family members, and in particular EGFR, activates other important downstream signalling pathways such as janus kinase and signal transducer and activator of transcription (JAK/STAT) and phospholipase C (PLC-γ)/Ca2+/calmodulin-dependant kinases, consequently leading to increased cell proliferation, reduced apoptosis, increased angiogenesis, migration, invasion, and resistance to chemotherapy and radiotherapy, which are the hallmarks of human cancer [13,18,19,20,21,22,23,24].