NSCLC cells resistant to cisplatin or paclitaxel showed elevated expression of several KDMs (3A, 4B, 5A, 6A), and the knockdown of KDM4B (but not 4A or 4D) or KDM6A most significantly sensitized cells to cisplatin, similarly to pharmacological inhibition using ML324 or JIB-04. Here, KDM6A is linked to non-small cell lung carcinoma.