KDM1A and cancer: In another study, novel 5-cyano-3-phenylindole-based LSD1 and HDAC dual-inhibitors were discovered, among which 7-(3-(3-Amino-2-methylphenyl)-5-cyano-1H-indol-1-yl)-N-hydroxyheptanamide (compound 20c) exhibited the best anti-cancer activity [229].