A clinical trial involving colon cancer patients conducted by Xu et al. demonstrated that curcumin inhibited FOXP3 gene transcription and expression, facilitating the conversion of FOXP3+ T regulatory cells into Th1 cells, while also blocking T regulatory cell-induced IFN-γ secretion from CD4+ T cells [84]. The gene discussed is FOXP3; the disease is malignant colon neoplasm.