Foremost among these is the substantial variation in PRKDC gene mutation frequencies across cancer types, with colon (9.66%), gastric (9.63%), and endometrial cancers (9.27%) exhibiting markedly higher mutation rates compared to thyroid cancer (0.99%), glioblastoma (1.37%), and hepatocellular carcinoma (1.61%) [180]. The gene discussed is PRKDC; the disease is hepatocellular carcinoma.