In another analysis, Tie-2 was not differentially expressed in PDAC or pancreatic neuroendocrine tumors when compared to normal pancreatic tissue; however, overexpression of Ang-2 gene and its gene products was found, indicating a role of Ang/Tie-2 in pancreatic tumors [50]. The gene discussed is ANGPT2; the disease is pancreatic neuroendocrine tumor.