CD163 and neoplasm: Gomez-Brouchet et al. linked high CD163+ tumor-associated macrophage (TAM) infiltration to improved overall and metastasis-free survival in OS, possibly due to tissue remodeling or antitumor roles [41], while Su et al. associated high CD68+CCL18+ M2 with lung metastasis and poor prognosis in OS, indicating a pro-tumorigenic subset [42].