Consistent with this, Zhu and colleagues showed that simultaneous activation of wild-type and/or mutant EGFR, combined with the deletion of Ink4A/Arf and PTEN tumor suppressor genes in the adult mouse brain, led to the rapid onset of highly aggressive gliomas that closely mimic the pathology of human glioblastoma. The gene discussed is CDKN2A; the disease is central nervous system cancer.