PIK3CA and neoplasm: Conversely, tumor suppressor miRNAs (e.g., miR-143, miR-27a, miR-205, and miR-369) targeted key genes, such as PLK1, PIK3CA, EGFR, AKT1, BCL2, HMGB1, MDM2, BCL2, RAF1, and CDKN1 (Figure 7), which have been described in the literature to initiate pathogenesis, enhance the proliferation, invasion, and migration of cancerous cells, tumor recurrence and progression, patient survival, and the prediction of the response to treatment [73,74,75].