HIF1A and familial hyperaldosteronism: Esters (such as Fumaric acid, 2-methylpentyl tridec-2-yn-1-yl ester in Table 2) suggest lipid remodeling, detoxification, or microbial metabolism, as well as TCA cycle disruption and onco-metabolic signaling, which are particularly linked to Fumarate Hydratase (FH) deficiency and HIF-1α stabilization [54,55,56].