Notably, the overlapping histologic features shared with other high-grade renal and mesenchymal neoplasms, such as MiTF family translocation RCC, fumarate hydratase-deficient RCC, epithelioid PEComa, and alveolar soft part sarcoma, can pose a significant diagnostic challenge and require thorough ancillary testing. Here, MITF is linked to renal cell carcinoma.