The first is characterised by CA125 levels of < 35 IU/ml, HE4 levels of ≥142 pmol/l, and the presence of tumour invasion of ≥ 1⁄2 of the myometrium, uterine serosal invasion, or cervical stromal invasion, as determined by ultrasound imaging; LNM probability in this group is 80%. Here, MUC16 is linked to neoplasm.