MUC16 and neoplasm: Surgical LN staging clearly is indicated in patients with CA125 levels ≥ 35 IU/ml, HE4 levels ≥ 103 pmol/l, and the presence of tumour invasion of ≥ 1⁄2 of the myometrium, uterine serosal invasion, or cervical stromal invasion; LNM probability in this group is 88%.