Despite the adverse conditions imposed by the tumor environment, tumor cells have developed a resilience program that ensures their survival through the expression of anti-apoptotic genes, including Bcl-2 Associated athanogene 1 (BAG1), BIRC2, XIAP, and members of the BCL2 family, thus enabling continued survival even under adverse conditions [133] (Figure 4). This evidence concerns the gene BCL2 and neoplasm.