CXCL1 released by iCAFs promotes multiple pro-tumorigenic processes: it recruits neutrophils and myeloid-derived suppressor cells (MDSCs) that dampen anti-tumor immunity, stimulates both direct and indirect angiogenesis, and induces epithelial-to-mesenchymal transition (EMT), migration, and cancer stem cell (CSC) expansion in tumor cells (Figure 1). This evidence concerns the gene CXCL1 and neoplasm.