SNCA and Parkinson disease: In Parkinson’s disease, the SNCA promoter was transcriptionally activated via H3K4me3 and was elevated in the substantia nigra of post-mortem PD brains, resulting in elevated alpha-synuclein expression, which was further investigated in cell models of the neuronal cell line SH-SY5Y and idiopathic PD-iPSC derived dopaminergic neurons.