UBE3C and head and neck cancer: LRP5 gene fusion with UBE3C results in the loss of the DKK-1 inhibitory domain; in a study of head and neck cancers, this fusion was found to stimulate Wnt/β-catenin signaling and upregulate MYC, CCND1, TCF4, and LEF13 expression, resulting in tumor cell proliferation [58].