ALKBH5 and thalassemia: Specifically, they discovered that the expression of the MTase complex components METTL16, WTAP, CBLL1, RBM15B, and ZC3H13 was lower in this type of α-thalassemia compared to normal erythroid cells, whereas the eraser protein ALKBH5, as well as the readers IGF2BP2 and YTHDF3, were overexpressed (Figure 3A).