In a cross-sectional study comparing plasma soluble TREM2 levels in 10 AD patients and 66 survivors of spontaneous intracerebral hemorrhage with cerebral amyloid angiopathy or hypertensive small-vessel disease, plasma-soluble TREM2 demonstrated an association with white matter hyperintensities, independently of amyloid and tau pathology. The gene discussed is TREM2; the disease is Alzheimer disease.