Furthermore, 46 TREM2 mutations associated with AD have been identified, including R62H (rs143332484), D87N (rs142232675), T96K (rs2234353), L211P (rs2234256), R136Q (rs149622783), and p.H157Y (rs2234255) [55,97,98,99,100,101,102], all of which increase the risk of AD development [103]. Here, TREM2 is linked to Alzheimer disease.