Some of the pathways that explore the association between PLK4 and different cancers such as endometrial cancer, hepatocellular carcinoma (HCC), glioma, lymphoma, neuroblastoma, thyroid cancer, colorectal cancer, etc., include Wnt/β-catenin [23,24], p53 [25], PI3K/AKT [26,27], Hippo/YAP [28] STING/NF-κB [29], ATR/CHEK1 [30] signaling, which are described below. The gene discussed is AKT1; the disease is central nervous system cancer.