In colorectal cancer, PUS7 regulates the PI3K/Akt/mTOR signaling cascade, where PUS7 knockdown in colorectal cancer cells led to reduced phosphorylation of PI3K, Akt, and mTOR, while PUS7 overexpression enhanced their phosphorylation in colon cancer cells. The gene discussed is PUS7; the disease is malignant colon neoplasm.