MAP2K4 and hypertensive disorder: Among the validated target genes, the genes with the potential to be implicated with hypertension or related conditions were SH2B1, ADM2, VEGFA, ITGA1, IRS1, COL8A1, SMAD9, SMAD2, EDN1, CYP11B2, YES1, KCNK3, WNT2B, CHP1, PLCD3, PCDH10, FOXC1, SLC39A8, SOX6, TMEM33, FBXW7, TLR3, MAP2K4, ALDH1A3, RNASEH2B, ARMT1, AK4, and CDH2 (Table S3).