A study showed the effect of cell type-specific ALDH1A3; upon upregulation, elevation of ALDH1A3 in endothelial cells supports their survival, while upregulation of ALDH1A3 in pulmonary arterial smooth muscle cells (PASMC) is reported to induce pathological proliferation and influence glycolytic metabolism, resulting in pulmonary arterial hypertension [20]. The gene discussed is ALDH1A3; the disease is pulmonary arterial hypertension.