Particularly, these findings agree with previous data from gastric cancer cells, in which suppression of PI3K/AKT by the PI3K inhibitor LY294002 or silencing AKT leads to decreased Wnt5-induced GSK-3 phosphorylation, which further causes reduced RhoA-dependent cell migration and actin remodeling [49]. This evidence concerns the gene AKT1 and gastric cancer.