Intriguingly, the differential impact of different cytokines/inflammatory mediators has been described for the first time as a precondition that can influence the impact of insulin on the intestinal epithelium, taking on the meaning of a prerequisite capable of piloting the transition from physiological function to physiopathological onset in an inflamed gastrointestinal context, both in a setting of insulin resistance and in its absence. Here, INS is linked to Insulin resistance.