Immune cells in TME include immunoreactive cells such as CD8 cytotoxic T lymphocytes (CTL)s, CD4 helper T cell, B lymphocytes, natural killer (NK) cells, dendritic cells (DC)s, M1 macrophages, and suppressive immune cells such as myeloid-derived suppressor cells (MDSC)s, tumor-associated macrophages (TAM)s, regulatory T cells (Treg)s, etc. [15] (Figure 1). This evidence concerns the gene CD8A and neoplasm.