CAFs-S1 (CD29Med FAPHiFSP1Med αSMAHigh PDGFRbMed-High CAV1Low) and CAF-S4 (CD29High FAPNeg FSP1Low-Med αSMAHigh PDGFRbLow-Med CAV1Low) subsets were detected preferentially in TNBC and HER-2-negative breast cancer. Here, ERBB2 is linked to breast cancer.